Intrinsic resistance to terbinafine among human and animal isolates of Trichophyton mentagrophytes related to amino acid substitution in the squalene epoxidase
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چکیده
منابع مشابه
Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine.
There has only been one clinically confirmed case of terbinafine resistance in dermatophytes, where six sequential Trichophyton rubrum isolates from the same patient were found to be resistant to terbinafine and cross-resistant to other squalene epoxidase (SE) inhibitors. Microsomal SE activity from these resistant isolates was insensitive to terbinafine, suggesting a target-based mechanism of ...
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We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.
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The effects of several physical and chemical agents on the survival of Trichophyton mentagrophytes arthrospores were investigated. Although arthrospores of this dermatophyte were highly resistant to chilling and freezing, they were extremely susceptible to moderate heat (above 50 degrees C) and desiccation. This high susceptibility could be significantly reduced when they were dried in the pres...
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ژورنال
عنوان ژورنال: Infection
سال: 2020
ISSN: 0300-8126,1439-0973
DOI: 10.1007/s15010-020-01498-1